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59983 Sigma

Josamycin

≥98.0% (UV)

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M,
InChI Key   XJSFLOJWULLJQS-NGVXBBESSA-N
assay   ≥98.0% (UV)
form   powder
color   white
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

Packaging

50 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

Biochem/physiol Actions

Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
Protocols & Articles
Peer-Reviewed Papers
15

References

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08168 Timestrip Plus 8 °C

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