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61327 Sigma

Lactoferrin from human milk

iron-saturated, ≥85% (GE)

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Properties

Related Categories Biochemicals and Reagents, Casein and Other Milk Proteins, Proteins and Derivatives More...
assay   ≥85% (GE)
quality   iron-saturated
mol wt   mol wt 82.4 kDa
concentration   ≥0.15 % (w/w) Fe
solubility   0.05 M NaCl: soluble1 mg/mL, clear to faintly turbid, faintly red to brown
storage temp.   2-8°C
Gene Information   human ... LTF(4057)

Description

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Application

Lactoferrin was used for development of lactoferrin immunosensor.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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