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62320 Sigma

(±)-α-Lipoic acid

≥98.0%

Synonym: (±)-1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL-α-Lipoic acid, DL-6,8-Thioctic acid, Lip(S2)

  • CAS Number 1077-28-7

  • Empirical Formula (Hill Notation) C8H14O2S2

  • Molecular Weight 206.33

  •  Beilstein Registry Number 81853

  •  EC Number 214-071-2

  •  MDL number MFCD00005474

  •  PubChem Substance ID 57651855

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Properties

Related Categories Acids, Acids & Bases, Antioxidant, Cell Biology, Chemical Synthesis,
InChI Key   AGBQKNBQESQNJD-UHFFFAOYSA-N
assay   ≥98.0% (HPLC)
  ≥98.0%
ign. residue   ≤0.1%
loss   ≤0.2% loss on drying
mp   60-62 °C
storage temp.   2-8°C
Gene Information   human ... ACHE(43), BCHE(590)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)

Description

Other Notes

Review

Packaging

5, 25 g in glass bottle

Biochem/physiol Actions

Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.

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Laboratory Gloves

All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
JP1192000
Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

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Peer-Reviewed Papers
15

References

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