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74155 Sigma

Nonactin

from Streptomyces sp., ≥97.0% (TLC)

Synonym: Ammonium ionophore

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,
biological source   from Streptomyces sp.
assay   ≥97.0% (TLC)
Mode of action   DNA synthesis | interferes
  cell membrane | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

General description

may contain the homologues monactin and dinactin

Other Notes

Natural macrotetrolide

Application

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, as an uncoupler of oxidative phosphorylation, and to inhibit surface expression of certain heat shock proteins (HSP60) .

Biochem/physiol Actions

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative phosphorylation .

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
RH1685000
Protocols & Articles
Peer-Reviewed Papers
15

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