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74667 Sigma

Nourseothricin sulfate

≥85% (HPLC)

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,
biological source   from Streptomyces noursei
assay   ≥85% (HPLC)
form   solid
color   white to light brown
solubility   H2O: soluble 200 mg/mL
suitability   suitable for (selection agent for molecular genetic research work)
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  fungi
  mycobacteria
  mycoplasma
  parasites
  viruses
  yeast
storage temp.   2-8°C

Description

Biochem/physiol Actions

Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.

Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.

Packaging

10mg, 100mg

Application

Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
RD4240000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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