• USA Home
  • 75618 - Vitamin K2 2,3-epoxide

EMAIL THIS PAGE TO A FRIEND
75618 Sigma

Vitamin K2 2,3-epoxide

≥98.0% (HPLC)

Synonym: 1a,7a-Dihydro-1a-methyl-7a-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]naphth[2,3-b]oxirene-2,7-dione, 2,3-Epoxymenaquinone, Menaquinone-4-epoxide, Menatetrenone epoxide, Menatetrenone-2,3-epoxide

  • CAS Number 72908-86-2

  • Empirical Formula (Hill Notation) C31H40O3

  • Molecular Weight 460.65

  •  PubChem Substance ID 329766174

Purchase

Properties

InChI Key   TUZHANAISKEZFG-GHDNBGIDSA-N
assay   ≥98.0% (HPLC)
storage temp.   −20°C

Description

Biochem/physiol Actions

Vitamin K2 2,3-epoxide is a vitamin K metabolite occurring in the ubiquinone, secondary metabolite and other terpenoid-quinone biosynthetic pathways. Vitamin K is needed for the post-translational modification of certain proteins, mostly required for blood coagulation. Within the cell, vitamin K undergoes electron reduction to a reduced form of vitamin K by the enzyme vitamin K epoxide reductase. Another enzyme then oxidizes vitamin K hydroquinone to allow carboxylation of glutamate to gamma-carboxyglutamate (Gla); this enzyme is called the gamma-glutamyl carboxylase or the vitamin K-dependent carboxylase. The carboxylation reaction will only proceed if the carboxylase enzyme is able to oxidize vitamin K hydroquinone to vitamin K epoxide at the same time; the carboxylation and epoxidation reactions are said to be coupled reactions. Vitamin K epoxide is then re-converted to vitamin K by the vitamin K epoxide reductase. These two enzymes comprise the so-called vitamin K cycle. One of the reasons why vitamin K is rarely deficient in a human diet is because vitamin K is continually recycled in our cells. Vitamin K 2,3-epoxide is the substrate for vitamin K 2,3-epoxide reductase (VKOR) complex. Significantly increased level of serum vitamin K epoxide has been found in patients with familial multiple coagulation factor deficiency.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?