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79470 Sigma

D(+)-2-Phosphoglyceric acid sodium salt hydrate

≥75% (calc. on dry substance, enzymatic)

Synonym: D-Glycerate 2-phosphate sodium salt, Sodium D-2-phosphoglycerate hydrate

  • CAS Number 83418-48-8 (anhydrous)

  • Empirical Formula (Hill Notation) C3H7O7P · xNa+ · yH2O

  • Molecular Weight 186.06 (anhydrous free acid basis)

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Properties

Related Categories Aerobic Glycolysis (the Warburg Effect), Cancer Metabolism, Cancer Research, Cell Biology, Metabolites of Aerobic Glycolysis (Warburg Effect),
assay   ≥75% (calc. on dry substance, enzymatic)
impurities   ≤1% Pi
  ≤35% water
storage temp.   −20°C

Description

Biochem/physiol Actions

Enantiomerically pure metabolite of glycolysis/gluconeogenesis and also substrate for a number of important enzymes in central metabolism like enolase and phosphoglycerate mutase.

The enzyme enolase is responsible for reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP). Phosphoglycerate mutase causes reversible isomerization of 3-phosphoglycerate and 2-phosphoglycerate in glycolysis and gluconeogenesis.

Packaging

1 g in poly bottle

50, 250 mg in poly bottle

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Biofiles, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Support, Transcription

Peer-Reviewed Papers
15

References

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