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81334 Sigma

Polymyxin B sulfate salt

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,
biological source   Fermentation of from Bacillus polymyxa
material   white to light yellow
form   powder
optical activity   [α]/D -78 to -90°
shelf life   3 yr
mol wt   mol wt 1450 g/mol
solubility   H2O: soluble50 mg/mL, clear to faintly turbid, colorless to yellow (<12.5 NTU)
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-negative bacteria
storage temp.   2-8°C

Description

Biochem/physiol Actions

Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.

Packaging

5 g in glass bottle

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TR1150000
Protocols & Articles
Peer-Reviewed Papers
15

References

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