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83907 Sigma

Rifampicin

≥97.0% (HPLC)

Synonym: 3-(4-Methylpiperazinyliminomethyl)rifamycin SV, Rifampin, Rifamycin AMP

  • CAS Number 13292-46-1

  • Empirical Formula (Hill Notation) C43H58N4O12

  • Molecular Weight 822.94

  •  Beilstein Registry Number 5723476

  •  EC Number 236-312-0

  •  MDL number MFCD00151389

  •  PubChem Substance ID 24888155

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,
InChI Key   JQXXHWHPUNPDRT-WLSIYKJHSA-N
assay   ≥97.0% (HPLC)
solubility   chloroform: soluble0.25 g/5mL
Mode of action   protein synthesis | interferes
storage temp.   2-8°C

Description

Biochem/physiol Actions

Inhibits the assembly of DNA and protein into mature virus particles.

Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

Application

Rifampicin is used as a selective cytochrome P4503A4 inducer. Studies have shown that rifampicin inhibits African Swine Fever Virus replication in tissue culture and inhibits the induction of tyrosine aminotransferase by cortisol in rat hepatoma cells grown in culture .

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
VJ7000000
Protocols & Articles

Articles

Inhibition of Nucleic Acid Synthesis by Antibiotics

Quinolones are a key group of antibiotics that interfere with DNA synthesis by inhibiting topoisomerase, most frequently topoisomerase II (DNA gyrase), an enzyme involved in DNA replication. DNA gyra...
BioFiles 2006, 1.4, 7.
Keywords: Antibiotics, Antitumor agents, Cancer, DNA replication

Peer-Reviewed Papers
15

References

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