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85590 Sigma

Spermine

≥99.0% (GC)

Synonym: N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine

  • CAS Number 71-44-3

  • Linear Formula NH2(CH2)3NH(CH2)4NH(CH2)3NH2

  • Molecular Weight 202.34

  •  Beilstein Registry Number 1750791

  •  EC Number 200-754-2

  •  MDL number MFCD00008215

  •  PubChem Substance ID 329769392

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type,
InChI Key   PFNFFQXMRSDOHW-UHFFFAOYSA-N
assay   ≥99.0% (GC)
form   crystalline (chunks)
  crystalline (chunks)
impurities   ≤0.5% spermidine
bp   150 °C/5 mmHg(lit.)
mp   28-30(lit.)
anion traces   carbonate (CO32-): ≤5000 mg/kg
storage temp.   2-8°C

Description

Application

Spermine, a polycationic biogenic polyamine derived from spermidine, may be used in a wide variety of biological applications as a supplement or regulatory agent.Used as co-matrix with DHB for MALDI-MS of sialylated glycans in negative ion mode.

Biochem/physiol Actions

Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

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Amplified Detection

Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3259PSN2 8 / PGII
WGK Germany 
3
RTECS 
EJ7175000
Flash Point(F) 
230 °F
Flash Point(C) 
110 °C
Protocols & Articles

Articles

HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide
Keywords: Chromatography, Clinical, Derivatizations, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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Description

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705330 Spermine-(butyl-d8) tetrahydrochloride, 97 atom % D, 95% (CP)
08168 Timestrip Plus 8 °C

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