• USA Home
  • 85605 - Spermine tetrahydrochloride

EMAIL THIS PAGE TO A FRIEND
85605 Sigma

Spermine tetrahydrochloride

BioUltra, for molecular biology, ≥99.5% (AT)

Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

  • CAS Number 306-67-2

  • Empirical Formula (Hill Notation) C10H26N4 · 4HCl

  • Molecular Weight 348.18

  •  Beilstein Registry Number 3911771

  •  EC Number 206-189-8

  •  MDL number MFCD00012914

  •  PubChem Substance ID 57653056

Purchase

Properties

Related Categories BioUltra, DNA & RNA Purification, Molecular Biology, Molecular Biology Reagents, Reagents More...
Quality Level   PREMIUM
grade   for molecular biology
InChI Key   XLDKUDAXZWHPFH-UHFFFAOYSA-N
product line   BioUltra
assay   ≥99.5% (AT)
impurities   DNases, none detected
  RNases, none detected
  insoluble matter, passes filter test
  phosphatases, none detected
  proteases, none detected
pH   4.5-7.0 (25 °C, 1 M in H2O)
mp   310-311 °C (dec.)(lit.)
solubility   H2O: 1 m at 20 °C clear, colorless to almost colorless
anion traces   sulfate (SO42-): ≤50 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   1 M in H2O
UV absorption   λ: 260 nm Amax: 0.2
  λ: 280 nm Amax: 0.15

Description

Application

Used to precipitate DNA from low salt aqueous buffers.

Other Notes

Spermine precipitation of DNA

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Price and Availability


Microcon Centrifugal Filters

All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
EJ7230000
Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?