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85605 Sigma

Spermine tetrahydrochloride

BioUltra, for molecular biology, ≥99.5% (AT)

Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

  • CAS Number 306-67-2

  • Empirical Formula (Hill Notation) C10H26N4 · 4HCl

  • Molecular Weight 348.18

  •  Beilstein Registry Number 3911771

  •  EC Number 206-189-8

  •  MDL number MFCD00012914

  •  PubChem Substance ID 57653056

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Properties

Related Categories BioUltra, DNA & RNA Purification, Molecular Biology, Molecular Biology Reagents, Reagents More...
Quality Level   PREMIUM
grade   for molecular biology
InChI Key   XLDKUDAXZWHPFH-UHFFFAOYSA-N
product line   BioUltra
assay   ≥99.5% (AT)
impurities   DNases, none detected
  RNases, none detected
  insoluble matter, passes filter test
  phosphatases, none detected
  proteases, none detected
pH   4.5-7.0 (25 °C, 1 M in H2O)
mp   310-311 °C (dec.)(lit.)
solubility   H2O: soluble1 m at 20 °C, clear, colorless to almost colorless
anion traces   sulfate (SO42-): ≤50 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   1 M in H2O
UV absorption   λ: 260 nm Amax: 0.2
  λ: 280 nm Amax: 0.15

Description

Application

Used to precipitate DNA from low salt aqueous buffers.

Other Notes

Spermine precipitation of DNA

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Microcon Centrifugal Filters

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
EJ7230000
Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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