• USA Home
  • 85610 - Spermine tetrahydrochloride

EMAIL THIS PAGE TO A FRIEND
85610 Sigma

Spermine tetrahydrochloride

≥99.0% (AT)

Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

  • CAS Number 306-67-2

  • Empirical Formula (Hill Notation) C10H26N4 · 4HCl

  • Molecular Weight 348.18

  •  Beilstein Registry Number 3911771

  •  EC Number 206-189-8

  •  MDL number MFCD00012914

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Enzyme Inhibitors,
InChI Key   XLDKUDAXZWHPFH-UHFFFAOYSA-N
Quality Level   PREMIUM
assay   ≥99.0% (AT)
mp   310-311 °C (dec.)(lit.)
solubility   H2O: soluble0.1 g/mL, clear
storage temp.   room temp

Description

Application

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Price and Availability


DISCOVER Bioactive Small Molecules

All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
EJ7230000

Documents

Certificate of Analysis

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?