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89385 Sigma

Thyroglobulin from bovine thyroid

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Properties

Related Categories Antibodies, Antibody Purification and Characterization, Carrier Proteins, Supplementary Products
mol wt   Mr ~660000
  mol wt ~670 kDa
concentration   ~0.6% iodine
solubility   H2O: 20 mg/mL hazy, yellow
storage temp.   −20°C
Gene Information   cow ... TG(280706)

Description

Application

Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Biochem/physiol Actions

Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Other Notes

Iodinated precursor protein of the thyroid hormones. Structure - function; Structure as deduced from base complementary DNA sequence

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

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Peer-Reviewed Papers
15

References

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