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  • 90182 - Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride

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90182 Sigma

Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride

≥99.0% (AT)

Synonym: (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride, (3S)-7-Amino-1-chloro-3-tosylamino-2-heptanone hydrochloride, TLCK, Tosyl-L-lysyl-chloromethane hydrochloride

  • CAS Number 4272-74-6

  • Empirical Formula (Hill Notation) C14H21ClN2O3S · HCl

  • Molecular Weight 369.31

  •  Beilstein Registry Number 7106867

  •  EC Number 224-266-4

  •  MDL number MFCD00065395

  •  PubChem Substance ID 57653369

  •  eCl@ss 32160406

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Organic Covalent Modifiers More...
InChI Key   YFCUZWYIPBUQBD-ZOWNYOTGSA-N
assay   ≥99.0% (AT)
optical activity   [α]20/D −7.8±0.5°, c = 2% in H2O
storage temp.   −20°C

Description

Other Notes

An alkylating reagent that may react with histidine or cysteine residues at the active site of enzymes. Inactivates serine proteases such as trypsin and clostripain . Chymotrypsin is not affected. To prevent proteolytic degradation, a combination of TLCK and TPCK can be used throughout the isolation of proteins, as in the isolation of histones.

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Laboratory Gloves

Biomedical Applications
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
XT5160000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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