Nα-Tosyl-L -lysine chloromethyl ketone hydrochloride
≥99.0% (AT)
DOWNLOAD MSDS (PDF)Synonym:
(3S)
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CAS Number 4272-74-6
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Empirical Formula (Hill Notation) C14H21ClN2O3S · HCl
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Molecular Weight 369.31
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Beilstein Registry Number 7106867
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EC Number 224-266-4
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MDL number MFCD00065395
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PubChem Substance ID 24889312
Properties
| Related Categories | Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Organic Covalent Modifiers More... |
| assay | ≥99.0% (AT) |
| optical activity | [α]20/D −7.8±0.5°, c = 2% in H2O |
| storage temp. | −20°C |
Description
Other Notes
An alkylating reagent that may react with histidine or cysteine residues at the active site of enzymes. Inactivates serine proteases such as trypsin 1,2,3 and clostripain 4. Chymotrypsin is not affected. To prevent proteolytic degradation, a combination of TLCK and TPCK can be used throughout the isolation of proteins, as in the isolation of histones.5
Price and Availability
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(TLCK treated to inactivate residual tryspin activity), Type VII, essentially salt-free, lyophilized powder, ≥40 units/mg protein
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