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92131 Sigma

Trimethoprim

crystallized, ≥99.0% (HPLC)

Synonym: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, NSC 106568

  • CAS Number 738-70-5

  • Empirical Formula (Hill Notation) C14H18N4O3

  • Molecular Weight 290.32

  •  Beilstein Registry Number 625127

  •  EC Number 212-006-2

  •  MDL number MFCD00036761

  •  PubChem Substance ID 24889615

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Biochemicals and Reagents,
InChI Key   IEDVJHCEMCRBQM-UHFFFAOYSA-N
assay   ≥99.0% (HPLC)
quality   crystallized
mp   199-203 °C
solubility   chloroform/ethanol (1:1): soluble50 mg/mL, clear, colorless
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  mycobacteria
storage temp.   2-8°C
Gene Information   human ... DHFRP1(573971), KCNH1(3756)
rat ... Dhfr(24312)

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Application

Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis and mechanism of resistance studies in Haemophilus influenzae .

Biochem/physiol Actions

Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).

Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Other Notes

Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UV8225000
Protocols & Articles
Peer-Reviewed Papers
15

References

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