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94675 Sigma

Valinomycin

≥98.0% (TLC)

Synonym: Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Antimycobacterial,
InChI Key   FCFNRCROJUBPLU-RPUZOQEISA-N
assay   ≥98.0% (TLC)
optical activity   [α]20/D +32±2°, c = 1.6% in benzene
mp   186-191 °C
Mode of action   cell membrane | interferes
antibiotic activity spectrum   mycobacteria
storage temp.   2-8°C

Description

Other Notes

Review

Biochem/physiol Actions

K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3
RTECS 
YV9468000
Protocols & Articles
Peer-Reviewed Papers
15

References

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