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95140 Sigma

Retinyl acetate

concentrate (~50% (w/w) in peanut oil), ~1500 U/mg

Synonym: Retinol acetate, Vitamin A acetate

  • CAS Number 127-47-9

  • Empirical Formula (Hill Notation) C22H32O2

  • Molecular Weight 328.49

  •  Beilstein Registry Number 1915439

  •  MDL number MFCD00019413

  •  PubChem Substance ID 57653653

  •  eCl@ss 34058009

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Properties

Related Categories Biochemicals and Reagents, Vitamin A, Vitamins More...
InChI Key   QGNJRVVDBSJHIZ-QHLGVNSISA-N
form   liquid
quality   concentrate (~50% (w/w) in peanut oil)
contains   DL-α-tocopherol as stabilizer
mp   57-58 °C
storage temp.   2-8°C

Description

Caution

crystallized product can be liquidified by heating to 65°C

Other Notes

isomeric purity: ~95% all-trans- and ~5% 13-cis-isomer

Review: Systematic mode of action of vitamin A

Unit Definition

1 U corresponds to 1 international unit acc. to Ph Eur II, 217 (1983)

Physical form

may partially crystallize

Biochem/physiol Actions

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinyl acetate is used in a wide range of biological applications.

Price and Availability


Laboratory Gloves

All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
Protocols & Articles

Articles

Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Sequences, Teratogens, Transcription, Type, Ubiquitinations, Usage, Vitamins

Peer-Reviewed Papers
15

References

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