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95200 Sigma

Vitamin B12a hydrochloride

≥96% (UV), ≥96% (HPLC)

Synonym: Hydroxocobalamin hydrochloride

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Properties

Related Categories Biochemicals and Reagents, Vitamin B, Vitamin B12, Vitamins
InChI Key   KEHNCSYXYMMUCO-BXSGNKEGSA-K
assay   ≥96% (HPLC)
  ≥96% (UV)
loss   ≤12% loss on drying, 20 °C (HV)
solubility   methanol: soluble10 mg/mL at 20 °C, clear, dark red
storage temp.   2-8°C

Description

Other Notes

Review

Biochem/physiol Actions

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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