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95746 Sigma

D-Xylulose 5-phosphate sodium salt

≥95% (TLC)

Synonym: Xu-5-P

  • CAS Number 138482-70-9

  • Empirical Formula (Hill Notation) C5H11O8P · xNa+

  • Molecular Weight 230.11 (free acid basis)

  •  PubChem Substance ID 24890198

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Properties

Related Categories Biochemicals and Reagents, Carbohydrates, Monosaccharide More...
assay   ≥95% (TLC)
storage temp.   −20°C

Description

Biochem/physiol Actions

D-Xylulose 5-phosphate (D-Xu-5-P) is a metabolite of the hexose monophosphate pathway activating protein phosphatase 2A to mediate the acute effects of carbohydrate feeding on the glycolytic pathway, the coordinated control of enzymes required in fatty acid & triglyceride synthesis. D-Xylulose 5-phosphate is the signal for the coordinated control of lipogenesis. The elevation of D-Xylulose 5-phosphate is the coordinating signal that both acutely activates phosphofructokinase in glycolysis and promotes the action of the transcription factor ChREBP to increase transcription of the genes for the enzymes of lipogenesis, the hexose mono-phosphate shunt, and glycolysis, all of which are required for the de novo synthesis of fat.

Xylulose-5-phoshate (Xu-5-P) is a metabolite of glucose via the pentose phosphate pathway. In the presence of excess glucose, liver Xu-5-P may act as a signaling molecule that regulates the nuclear transport of carbohydrate response element binding protein (ChREBP), a transcription factor that induces the expression of enzymes involved in glucose metabolism and lipogenesis.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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