| Properties
| Related Categories | 4.2.x.x C-O bonds, 4.x.x.x Lyases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates More... |
Description
Other Notes
Currently available only in Europe.
Unit Definition
1 Trp-U corresponds to the amount of enzyme which produces 0.1 μmol of tryptophan in 20 minutes at pH 7.8 and 37 °C.
Application
Tryptophan synthase is an α2β2 enzyme that catalyzes the final two steps in the biosynthesis of L-tryptophan. It is used to study tryptophan inhibitors to treat various diseases, to study the plasticity of the tryptophase synthase active site and to study allosteric communication 1. Product 96159 produces tryptophan at pH 7.8 and 37 °C.
Biochem/physiol Actions
The α subunit cleaves indole-3-glycerol phosphate into indole and glyceraldehyde 3-phosphate. Indole is then channeled to the active site of the β-subunit and condensed with PLP-bound α-aminoacrylate. Tryptophan synthase is allosterically regulated 1.
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