Aconitase from porcine heart
DOWNLOAD MSDS (PDF)Synonym: Aconitate hydratase, Citrate (isocitrate) hydrolyase
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CAS Number 9024-25-3
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MDL number MFCD00130335
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Popular Documents: Product Information Sheet (PDF)
| Properties
| Related Categories | 4.2.x.x C-O bonds, 4.x.x.x Lyases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, |
| storage temp. | −20°C |
Description
Analysis Note
Crude preparation containing aconitase activity
Unit Definition
One unit will convert 1.0 μmole of citrate (via cis-aconitate) to isocitrate per min at pH 7.4 at 25 °C.
Application
Aconitase may be usefull in diabetes research 1as well as to study structural conservation between iron-responsive element binding proteins (IRE-BP) and isomerases 2.
Biochem/physiol Actions
Aconitase catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle. Aconitase is inhibited by cyanide, sulfide and copper and mercury at low concentrations. It is competitively inhibited by trans-aconitate. Aconitase contains an internal Fe-S cluster which is responsible for its activity.
Price and Availability
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