|Related Categories||A - K, A-AM, Antibacterial, Antibiotics, Antibiotics A to Z,|
|Gene Information||human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)|
Actinonin is an inhibitor of leucine aminopeptidase. Actinonin has also been used to improve antibacterial activity and antiobesity therapeutics.
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The term ‘neuropeptidases’ refers to those enzymes that participate in the inactivation of synaptically released neuropeptides and therefore serve to turn off the generated peptide signal. In general...
Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. Minder P, Bayha E, Becker-Pauly C, et al. J. Biol. Chem. 287(42), 35201-11, (2012)
Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells. Pratt J, Roy R, and Annabi B Glycobiology 22(9), 1245-55, (2012)
Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi. Rodrígues-Poveda CA, Pérez-Moreno G, Vidal AE, et al. Mol. Biochem. Parasitol. 182(1-2), 83-7, (2012)
Trapping conformational states along ligand-binding dynamics of peptide deformylase: the impact of induced fit on enzyme catalysis. Fieulaine S, Boularot A, Artaud I, et al. PLoS Biol. 9(5), e1001066, (2011)
Over-expression of peptide deformylase in chloroplasts confers actinonin resistance, but is not a suitable selective marker system for plastid transformation. Fernández-San Millán A, Obregón P, and Veramendi J Transgenic Res. 20(3), 613-24, (2011)
The novel endomorphin degradation blockers Tyr-Pro-DClPhe-Phe-NH (EMDB-1) and Tyr-Pro-Ala-NH (EMDB-2) prolong endomorphin-2 action in rat ileum in vitro. Fichna J, Perlikowska R, Gach K, et al. Chem. Biol. Drug Des. 76(1), 77-81, (2010)
A protease inhibitor discovery method using fluorescence correlation spectroscopy with position-specific labeled protein substrates. Nakata H, Ohtsuki T, and Sisido M Anal. Biochem. 390(2), 121-5, (2009)
Delineation of alternative conformational states in Escherichia coli peptide deformylase via thermodynamic studies for the binding of actinonin. Berg AK and Srivastava DK Biochemistry 48(7), 1584-94, (2009)
Modulation of cytokine production and silica-induced lung fibrosis by inhibitors of aminopeptidase N and of dipeptidyl peptidase-IV-related proteases. Kühlmann UC, Chwieralski CE, van den Brule S, et al. Life Sci. 84(1-2), 1-11, (2009)
Effects of an antibiotic protease inhibitor, actinonin on the growth within collagen gels of non-metastatic and metastatic mouse mammary tumors of the same origin. Sayama, K., et al. Cancer Lett. 94, 171, (1995)
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