AC-55649
≥98% (HPLC), solid
DOWNLOAD MSDS (PDF)Synonym: 4′-Octyl-4-biphenylcarboxylic acid, 4′-n-octylbiphenyl-4-carboxylic acid, 8BCA
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CAS Number 59662-49-6
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Empirical Formula (Hill Notation) C21H26O2
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Molecular Weight 310.43
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MDL number MFCD00157040
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PubChem Substance ID 24724405
Properties
| Related Categories | A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, |
| assay | ≥98% (HPLC) |
| form | solid |
| solubility | DMSO: >7 mg/mL |
| storage temp. | 2-8°C |
| Gene Information | human ... RARB(5915) |
Description
Biochem/physiol Actions
AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580.
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