Bcl-w (Minus C-Terminus) human >95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

Properties

Related Categories	Apoptosis and Cell Cycle, Bcl-2 Family Proteins, Bcl-2 Family Proteins and Antibodies, Cell Biology, Cell Signaling and Neuroscience More...
recombinant	expressed in E. coli
assay	>95% (SDS-PAGE)
form	buffered aqueous glycerol solution
mol wt	mol wt 18 kDa by SDS-PAGE
shipped in	wet ice
storage temp.	−20°C
Gene Information	human ... BCL2L2(599)

Description

Analysis Note

Measured by its ability to inhibit caspase-8-cleaved human BID-mediated release of cytochrome c from isolated mouse liver mitochondria using ELISA.

Physical form

Supplied as a 0.2 μm filtered solution in 25 mM HEPES, pH 7.5, 0.1 M KCl, and 10% glycerol.

Biochem/physiol Actions

Like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Bcl-w is an anti-apoptotic member of the Bcl-2 family that prevents release of cytochrome c from the mitochondrial intermembrane space into the cytosol. It is required for normal sperm maturation. Natural Bcl-w contains a C-terminal mitochondrial targeting sequence.