|Related Categories||Apoptosis and Cell Cycle, Bcl-2 Family Proteins, Bcl-2 Family Proteins and Antibodies, Biochemicals and Reagents, Cell Biology,|
|recombinant||expressed in E. coli|
|description||full-length murine Bad with an N-terminal histidine-tag.|
|form||buffered aqueous glycerol solution|
|mol wt||mol wt 31 kDa|
|Gene Information||mouse ... Bad(12015)|
Supplied as a solution in phosphate buffered saline containing 250 mM imidizole and 50% glycerol.
Bad, a pro-apoptotic factor, is a member of the Bcl-2 family. Cytokine-induced phosphorylation of Bad results in it being sequested in the cytosol. In the absence of cytokines such as interleukin 3 (IL-3), Bad dephosphorylation occurs, causing the release of cytochrome c from the mitochondria.
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