|Related Categories||Apoptosis and Cell Cycle, Bcl-2 Family Proteins, Bcl-2 Family Proteins and Antibodies, Biochemicals and Reagents, Cell Biology,|
|recombinant||expressed in E. coli|
|description||full-length murine Bad with an N-terminal histidine-tag.|
|form||buffered aqueous glycerol solution|
|mol wt||mol wt 31 kDa|
|Gene Information||mouse ... Bad(12015)|
Supplied as a solution in phosphate buffered saline containing 250 mM imidizole and 50% glycerol.
Bad, a pro-apoptotic factor, is a member of the Bcl-2 family. Cytokine-induced phosphorylation of Bad results in it being sequested in the cytosol. In the absence of cytokines such as interleukin 3 (IL-3), Bad dephosphorylation occurs, causing the release of cytochrome c from the mitochondria.
Several protein kinases are activated by the MAPK family members p38α (SAPK2a) and ERKs 1 and 2. The MAPKAP kinases can be subdivided into two groups; those comprising two kinase domains in a single ...
The Ste20 (Sterile 20) protein kinase family consists of enzymes with sequence homology to the yeast MAP4K Ste20p in the pheromone response pathway. Based on phylogenetic relationships, they can be d...
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