|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antifungal,|
|potency||1.5-2.0 units per mg|
|solubility||H2O: soluble20 mg/mL, clear, colorless|
|cation traces||Cu: ≤0.10%|
|suitability||suitable for cell culture|
Recommended for use as a selection agent at 10-100 μg/ml.
Bleomycin is used as a transformed cell selection agent, especially for plant transformants. Recommended for use at 10-100 g/ml. It is also used to induce pulmonary fibrosis and epithelial cell apoptosis. 1,2,3
An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective cleavage of RNA. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis.
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crystalline, 1.5-2.0 units/mg solid
1.5-2.0 units/mg solid, BioReagent, suitable for cell culture
for fluorescence, mixture of bleomycin sulfate salts, lyophilized, powder, white
synthetic, ≥98%, powder
Certificate of Analysis
Certificate of Origin
|Personal Protective Equipment||Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||46-63-40|
|Safety Statements (Europe)||36/37-45|
Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription
[Effectiveness and toxicity of MOPP, ABVD, BEACOPP chemotherapy in first-diagnosed Hodgkin lymphoma with a poor prognosis]. Filatova LV, Plotnikova AA, Gershanovich ML, et al. Vopr. Onkol. 59(2), 59-65, (2013)
Phase III randomised controlled trial of neoadjuvant chemotherapy plus radical surgery vs radical surgery alone for stages IB2, IIA2, and IIB cervical cancer: a Japan Clinical Oncology Group trial (JCOG 0102). Katsumata N, Yoshikawa H, Kobayashi H, et al. Br. J. Cancer 108(10), 1957-63, (2013)
Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. Radovanac K, Morgner J, Schulz JN, et al. EMBO J. 32(10), 1409-24, (2013)
Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin. Kach J, Sandbo N, Sethakorn N, et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 304(11), L757-64, (2013)
Suppression of nuclear factor erythroid 2-related factor 2 via extracellular signal-regulated kinase contributes to bleomycin-induced oxidative stress and fibrogenesis. Liu R, Chen H, Bai H, et al. Toxicol. Lett. 220(1), 15-25, (2013)
Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: a biphasic experimental study. Chitra P, Saiprasad G, Manikandan R, et al. Toxicol. Lett. 219(2), 178-93, (2013)
International validation study for interim PET in ABVD-treated, advanced-stage hodgkin lymphoma: interpretation criteria and concordance rate among reviewers. Biggi A, Gallamini A, Chauvie S, et al. J. Nucl. Med. 54(5), 683-90, (2013)
Peptide-mediated inhibition of mitogen-activated protein kinase-activated protein kinase-2 ameliorates bleomycin-induced pulmonary fibrosis. Vittal R, Fisher A, Gu H, et al. Am. J. Respir. Cell. Mol. Biol. 49(1), 47-57, (2013)
miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1. Lino Cardenas CL, Henaoui IS, Courcot E, et al. PLoS Genet. 9(2), e1003291, (2013)
Gene expression profiles reveal molecular mechanisms involved in the progression and resolution of bleomycin-induced lung fibrosis. Cabrera S, Selman M, Lonzano-Bolaños A, et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 304(9), L593-601, (2013)
Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression. Tanaka R, Watanabe H, Kodama A, et al. J. Pharmacol. Exp. Ther. 345(2), 271-83, (2013)
Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model. Stegemann A, Sindrilaru A, Eckes B, et al. Arthritis Rheum. 65(3), 792-804, (2013)
Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models. Schirner, M., et al. Clin. Cancer Res. 4, 1331-1336, (1998)
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