|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antifungal,|
|potency||1.5-2.0 units per mg|
|solubility||H2O: soluble20 mg/mL, clear, colorless|
|cation traces||Cu: ≤0.10%|
|suitability||suitable for cell culture|
Recommended for use as a selection agent at 10-100 μg/ml.
Bleomycin is used as a transformed cell selection agent, especially for plant transformants. Recommended for use at 10-100 g/ml. It is also used to induce pulmonary fibrosis and epithelial cell apoptosis. 1,2,3
An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective cleavage of RNA. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis.
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crystalline, 1.5-2.0 units/mg solid
1.5-2.0 units/mg solid, BioReagent, suitable for cell culture
for fluorescence, mixture of bleomycin sulfate salts, lyophilized, powder, white
synthetic, ≥98%, powder
Certificate of Analysis
Certificate of Origin
|Personal Protective Equipment||Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||46-40|
|Safety Statements (Europe)||36/37-45|
Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription
Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models. Schirner, M., et al. Clin. Cancer Res. 4, 1331-1336, (1998)
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|15361||Bleomycin sulfate from Streptomyces verticillus, for fluorescence, mixture of bleomycin sulfate salts, lyophilized, powder, white|
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