Bleomycin sulfate from Streptomyces verticillus
BioXtra, crystalline
DOWNLOAD MSDS (PDF)Synonym: Blenoxane, Bleo, Blexane
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CAS Number 9041-93-4
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EC Number 232-925-2
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MDL number MFCD00070310
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PubChem Substance ID 24891650
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Popular Documents: Specification Sheet (PDF)
Properties
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antifungal, |
| product line | BioXtra |
| form | crystalline |
| potency | 1.5-2.0 units per mg |
| solubility | H2O: soluble20 mg/mL, clear, colorless |
| cation traces | Cu: ≤0.10% |
| suitability | suitable for cell culture |
| storage temp. | 2-8°C |
Description
Application
Recommended for use as a selection agent at 10-100 μg/ml.
Bleomycin is used as a transformed cell selection agent, especially for plant transformants. Recommended for use at 10-100 g/ml. It is also used to induce pulmonary fibrosis and epithelial cell apoptosis. 1,2,3
Biochem/physiol Actions
An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective cleavage of RNA. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis.
Protocols & Applications
Price and Availability
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