|Related Categories||Allium cepa (Onion), Biochemicals and Reagents, Cell Biology, Lipids, Metabolic Pathways,|
|biological source||from semisynthetic|
Brassicasterol is a phytosterol found in rapeseed and canola oils; it is also present in marine algae and shellfish. Brassicasterol has been shown to inhibit sterol Δ24-reductase, an enzyme involved in the mammalian cholesterol biosynthesis pathway.4
Brassicasterol is a plant sterol, structurally similar to cholesterol. Plant sterols compete with cholesterol and reduce the content of cholesterol incorporated into micelles thereby reducing its absorption. Brassicasterol reportedly decreases the progression of atherosclerosis.2 The level of brassicasterol in cerebrospinal fluid may be used as a prognostic factor for progression of Alzheimer′s disease.3
Brassicasterol is from a semi-synthetic source. It yields clear, colorless solution in chloroform at 50 mg/ml.
Brassicasterol was used as standard to analyze the sterols from mussels sample by thin layer chromatography.1
The amount of cholesterol that is synthesized in the liver is tightly regulated by dietary cholesterol levels. When dietary intake of cholesterol is high, synthesis is decreased and when dietary inta...
BioFiles 2007, 2.7, 6.
Keywords: Gene expression, Transcription
1. Fatty acid and sterol composition of frozen and freeze-dried New Zealand Green Lipped Mussel (Perna canaliculus) from three sites in New Zealand Murphy KJ et al Asia Pac. J. Clin. Nutr. 12, 50-60, (2003)
2. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels Tansley G et al Curr. Gerontol. Geriatr. Res., doi: 10.1155/2012/179318, (2012)
Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis. Pereira M, Song Z, Santos-Silva LK, et al. Biochim. Biophys. Acta 1801, 1163-1174, (2010)
The search of new biomarkers to identify Alzheimer's disease: an editorial comment to T. Vanmierlo et al. 'The plant sterol brassicasterol and additional CFS biomarker in Alzheimer's Disease' (1). Lobo A, Quintanilla MA. Acta Psychiatr. Scand. 124, 163-164, (2011)
Plants steroid hormones, brassinosteroids: current highlights of molecular aspects on their synthesis/metabolism, transport, perception and response. Bishop, G.J., and Yokota, T. Plant Cell Physiol. 42, 114-20, (2001)
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