|Related Categories||Biochemicals and Reagents, Cell Biology, Cholesterol and Derivatives, Lipids, Metabolic Pathways,|
|assay||≥98% (HPLC; detection at 205 nm)|
The most abundant cholesteryl ester in low density lipoprotein (LDL).
Cholesteryl linoleate is a major cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters.3 The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.4
Cholesteryl linoleate yields clear, colorless solution in chloroform at 100 mg/ml.
Cholesteryl linoleate was cosonicated with cholesterol to prepare dispersions were prepared to study the cholesterol to phospholipid ratio in red blood cell membrane.1 It was used as HPLC standard in the analysis of rat liver lipoproteins.2
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To more efficiently transport both dietary and synthesized cholesterol, it is converted to cholesteryl esters. Free cholesterol can be taken up by lipoproteins, but is confined to the outer surface o...
BioFiles 2007, 2.7, 10.
1. Factors influencing the lipid composition and fluidity of red cell membranes in vitro: production of red cells possessing more than two cholesterols per phospholipid Cooper RA et al Biochemistry 17, 327-31, (1978)
3. Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle Krieger M et al J. Biol. Chem. 253, 4093-101, (1978)
Omapatrilat decreased macrophage oxidative status and atherosclerosis progression in atherosclerotic apolipoprotein E-deficient mice. Hayek T, Hamoud S, Keidar S, et al. J. Cardiovasc. Pharmacol. 43, 140-147, (2004)
Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid. Do TQ, Moshkani S, et al. J. Immunol. 181, 4177-4187, (2008)
Cannabidiol-2',6'-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro. Takeda S, Hirayama A, Urata S, et al. Biol. Pharm. Bull. 34(8), 1252-6, (2011)
Intramural coronary lipid injection induces atheromatous lesions expressing proinflammatory chemokines: implications for the development of a porcine model of atherosclerosis. Tellez A, Schuster DS, Alviar C, et al. Cardiovasc. Revasc. Med. 12(5), 304-11, (2011)
Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Ohshiro T, Matsuda D, Sakai K, et al. Arterioscler. Thromb. Vasc. Biol. 31(5), 1108-15, (2011)
Modification of composition of a nanoemulsion with different cholesteryl ester molecular species: effects on stability, peroxidation, and cell uptake. Almeida CP, Vital CG, Contente TC, et al. Int. J. Nanomedicine 5, 679-86, (2010)
Endovascular needle injection of cholesteryl linoleate into the arterial wall produces complex vascular lesions identifiable by intravascular ultrasound: early development in a porcine model of vulnerable plaque. Granada JF, Moreno PR, Burke AP, et al. Coron. Artery Dis. 16(4), 217-24, (2005)
Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. Milne GL, Seal JR, Havrilla CM, et al. J. Lipid Res. 46(2), 307-19, (2005)
Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway. Huber J, Boechzelt H, Karten B, et al. Arterioscler. Thromb. Vasc. Biol. 22(4), 581-6, (2002)
When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid. Bagnati M, Perugini C, Cau C, et al. Biochem. J. 340 ( Pt 1), 143-52, (1999)
Accumulation and metabolism of low density lipoprotein-derived cholesteryl linoleate hydroperoxide and hydroxide by macrophages. Kritharides L, Upston J, Jessup W, et al. J. Lipid Res. 39(12), 2394-405, (1998)
Quantitative analysis of cholesterol and cholesteryl esters in human atherosclerotic plaques using near-infrared Raman spectroscopy. Weinmann P, Jouan M, Nguyen QD, et al. Atherosclerosis 140(1), 81-8, (1998)
The reduction of cholesteryl linoleate in lipoproteins: an index of clinical severity in beta-thalassemia/Hb E. Luechapudiporn R, Morales NP, Fucharoen S, et al. Clin. Chem. Lab Med. 44(5), 574-81, (2006)
Regioisomeric distribution of cholesteryl linoleate hydroperoxides and hydroxides in plasma from healthy humans provides evidence for free radical-mediated lipid peroxidation in vivo. Mashima R, Onodera K, and Yamamoto Y J. Lipid Res. 41(1), 109-15, (2000)
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