|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,|
|solubility||ethanol: soluble10 mg/mL|
|Gene Information||human ... SLC2A1(6513), SLC2A4(6517)|
Inhibits natural killer (NK) cell activity in a dose-dependent manner without affecting target cell binding. Shown to inhibit insulin-induced translocation of both GLUT4 and GLUT1 in a dose-dependent manner. Also reported to inhibit agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells.
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Certificate of Origin
The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Transcription
Free calcium is a major second messenger in all cell types. One mechanism by which calcium ions exert their effects is by binding to a 17 kDa protein, calmodulin (CaM). The binding of four calcium io...
Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism ...
Linda Stephenson, Ph.D.
Biofiles v6 n4, 2011
Keywords: Apoptosis, Biological processes, Carboxylations, Diabetes, Gene expression, Gluconeogenesis, Glycolysis, Hormones, Metabolism, Metabolites, Transcription, Transduction
Roles of inhibitors of myosin light chain kinase and tyrosine kinase on cation influx in agonist-stimulated endothelial cells. Takahashi, R., et al. Biochem. Biophys. Res. Commun. 235, 657-662, (1997)
Interleukin-18 facilitates neutrophil transmigration via myosin light chain kinase-dependent disruption of occludin, without altering epithelial permeability. Lapointe TK and Buret AG Am. J. Physiol. Gastrointest. Liver Physiol. 302(3), G343-51, (2012)
Linalyl acetate as a major ingredient of lavender essential oil relaxes the rabbit vascular smooth muscle through dephosphorylation of myosin light chain. Koto R, Imamura M, Watanabe C, et al. J. Cardiovasc. Pharmacol. 48(1), 850-6, (2006)
Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium. Wang GY, McCloskey DT, Turcato S, et al. Am. J. Physiol. Heart Circ. Physiol. 291(4), H2013-7, (2006)
Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. Shimizu S, Yoshida T, Wakamori M, et al. J. Physiol. 570(Pt 2), 219-35, (2006)
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats. Weigand L, Sylvester JT, and Shimoda LA Am. J. Physiol. Lung Cell. Mol. Physiol. 290(2), L284-90, (2006)
Myosin light chain kinase and Rho-kinase participate in P2Y receptor-mediated acceleration of permeability through the endothelial cell layer. Tanaka N, Nejime N, Kubota Y, et al. J. Pharm. Pharmacol. 57(3), 335-40, (2005)
Murine vasa recta pericyte chloride conductance is controlled by calcium, depolarization, and kinase activity. Lin H, Pallone TL, and Cao C Am. J. Physiol. Regul. Integr. Comp. Physiol. 299(5), R1317-25, (2010)
Real-time monitoring of angiotensin II-induced contractile response and cytoskeleton remodeling in individual cells by atomic force microscopy. Cuerrier CM, Benoit M, Guillemette G, et al. Pflugers Arch. 457(6), 1361-72, (2009)
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