|Related Categories||Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,|
|biological source||from Canavalia ensiformis|
|solubility||H2O: <100 mg/mL|
A naturally occurring
Canavanine is a naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). Overproduction of NO by iNOS plays a crucial role in the pathophysiology of septic shock and chronic inflammation.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C1625.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Certificate of Analysis
Certificate of Origin
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||20/21/22|
|Safety Statements (Europe)||36|
Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells. Vynnytska BO, Mayevska OM, et al. Anticancer Drugs 22, 148-157, (2011)
Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe. Ohtsuka H, Ogawa S, Kawamura H, et al. Mol. Genet. Genomics 288(5-6), 285-95, (2013)
Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis. Cabrera M, Arlt H, Epp N, et al. J. Biol. Chem. 288(7), 5166-75, (2013)
Quantification of canavanine, 2-aminoethanol, and cyanamide in Aphis craccivora and its host plants, Robinia pseudoacacia and Vicia angustifolia: effects of these compounds on larval survivorship of Harmonia axyridis. Kamo T, Tokuoka Y, and Miyazaki M J. Chem. Ecol. 38(12), 1552-60, (2012)
Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Jézégou A, Llinares E, Anne C, et al. Proc. Natl. Acad. Sci. U. S. A. 109(50), E3434-43, (2012)
Interactions between phytochemical components of Sutherlandia frutescens and the antiretroviral, atazanavir in vitro: implications for absorption and metabolism. Müller AC, Patnala S, Kis O, et al. J. Pharm. Pharm. Sci. 15(2), 221-33, (2012)
Compromised cellular responses to DNA damage accelerate chronological aging by incurring cell wall fragility in Saccharomyces cerevisiae. Yu S, Zhang XE, Chen G, et al. Mol. Biol. Rep. 39(4), 3573-83, (2012)
Characterization and isolation of mutants producing increased amounts of isoamyl acetate derived from hygromycin B-resistant sake yeast. Inoue T, Iefuji H, and Katsumata H Biosci. Biotechnol. Biochem. 76(1), 60-6, (2012)
Amino acid analog toxicity in primary rat neuronal and astrocyte cultures: implications for protein misfolding and TDP-43 regulation. Dasuri K, Ebenezer PJ, Uranga RM, et al. J. Neurosci. Res. 89(9), 1471-7, (2011)
Nitrogen supply and abiotic stress influence canavanine synthesis and the productivity of in vitro regenerated Sutherlandia frutescens microshoots. Colling J, Stander MA, and Makunga NP J. Plant Physiol. 167(17), 1521-4, (2010)
Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, on lactate metabolism and muscle high energy phosphates during endotoxic shock in rats. Levy, B., et al. Shock 11, 98-103, (1999)
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