|Related Categories||Biochemicals and Reagents, Cell Biology, Cholesterol and Derivatives, Lipids, Metabolic Pathways,|
5α-Cholest-7-en-3β-ol yields clear, colorless solution in chloroform at 10 mg/ml.
5α-Cholest-7-en-3β-ol was used as a substrate in enzymatic assay for plasma cholesterol.1 It was used to supplement diet of Daphnia galeata to study the effect on life-history traits.2
5α-Cholest-7-en-3β-ol (Lathosterol) is an intermediate in cholesterol biosynthesis pathway.3 Lathosterol in serum is carried on lipoproteins and is indicative of the rate of cholesterol synthesis. It acts as a marker of synthesis of cholesterol and is not affected by dietary consumption of cholesterol.4
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C3652.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients. Thongtang N, Lin J, Schaefer EJ, et al. Atherosclerosis 225(2), 388-96, (2012)
Liver fat content is associated with an increase in cholesterol synthesis independent of statin therapy use in patients with type 2 diabetes. Brindisi MC, Guiu B, Duvillard L, et al. Atherosclerosis 224(2), 465-8, (2012)
Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans. Nochioka K, Tanaka S, Miura M, et al. Circ. J. 76(8), 2023-30, (2012)
Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms. Besga A, Cedazo-Minguez A, Kåreholt I, et al. Neurosci. Lett. 510(2), 121-6, (2012)
Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses. Saraiva D, Semedo R, Castilho Mda C, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(32), 3806-11, (2011)
Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19. Gälman C, Angelin B, and Rudling M J. Intern. Med. 270(6), 580-8, (2011)
Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects. Niesor EJ, Chaput E, Staempfli A, et al. Atherosclerosis 219(2), 761-7, (2011)
A calorimetric and spectroscopic comparison of the effects of lathosterol and cholesterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. Benesch MG, Mannock DA, Lewis RN, et al. Biochemistry 50(46), 9982-97, (2011)
Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome. Richard C, Couture P, Desroches S, et al. Br. J. Nutr. 107(5), 705-11, (2012)
Simultaneous determination of serum lathosterol and cholesterol by semi-micro high-performance liquid chromatography with electrochemical detection. Hojo K, Hakamata H, and Kusu F J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(11-12), 751-5, (2011)
Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans. Persson L, Cao G, Ståhle L, et al. Arterioscler. Thromb. Vasc. Biol. 30(12), 2666-72, (2010)
Promoter variant -204A > C of the cholesterol 7α-hydroxylase gene: association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells. De Castro-Orós I, Pampín S, Cofán M, et al. Clin. Nutr. 30(2), 239-46, (2011)
Long-term effects of ezetimibe-plus-statin therapy on low-density lipoprotein cholesterol levels as compared with double-dose statin therapy in patients with coronary artery disease. Okada K, Iwahashi N, Endo T, et al. Atherosclerosis 224(2), 454-6, (2012)
Plasma sterol evidence for decreased absorption and increased synthesis of cholesterol in insulin resistance and obesity. Paramsothy P, Knopp RH, Kahn SE, et al. Am. J. Clin. Nutr. 94(5), 1182-8, (2011)
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. Shinkyo R, Xu L, Tallman KA, et al. J. Biol. Chem. 286(38), 33021-8, (2011)
The effects of phytosterols present in natural food matrices on cholesterol metabolism and LDL-cholesterol: a controlled feeding trial. Lin X, Racette SB, Lefevre M, et al. Eur. J. Clin. Nutr. 64(12), 1481-7, (2010)
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