Cytochrome c from equine heart BioReagent, suitable for GFC marker

Properties

Related Categories	Cytochrome c Control Proteins, Cytochromes, Electron Transport and Cellular Respiration, Gel Filtration Chromatography, Metabolic Pathways, Metabolomics, Molecular Weight Markers, Protein Chromatography, Proteomics More...
product line	BioReagent
mol wt	mol wt ~12,400
packaging	vial of ≥10 mg
suitability	suitable for GFC marker
storage temp.	−20°C

Description

Frequently Asked Questions

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Biochem/physiol Actions

Cytochrome c is primarily known as an electron-carrying mitochondrial protein. The transition of cytochrome c between the ferrous and ferric states within the cell makes it an efficient biological electron-transporter and it plays a vital role in cellular oxidations in both plants and animals. It is generally regarded as a universal catalyst of respiration, forming an essential electron-bridge between the respirable substrates and oxygen

Other Notes

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

Application

Cytochrome c is primarily known as an electron-carrying mitochondrial protein and is generally regarded as a universal catalyst of respiration. Cytochrome c can be used as a gel filtration molecular weight marker in gel filtration chromatography and protein chromatography and can be used to study cytochrome c control proteins, electron transport and cellular respiration.

The specific sites and extent of oxidation in horse cytochrome c treated with H₂O₂ and UV were characterized. It was suggested that the state of these sites could be used as a biomarker for the oxidative environment in a cell.

Price and Availability

Suggested Laboratory Gloves

This substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.

for splash & immersion protection

Related Papers

The effects of ATP and sodium chloride on the cytochrome c-cardiolipin interaction: the contrasting behavior of the horse heart and yeast proteins. Sinibaldi, F., et al. J. Inorg. Biochem. 105, 1365-1372, (2011)

Documents

Certificate of Analysis

Certificate of Origin

Ask A Scientist

C7150 - Bulletin (89KB)

C7150 - General Information (93KB)

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany	3
RTECS	HA5365000

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Papers

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The effects of ATP and sodium chloride on the cytochrome c-cardiolipin interaction: the contrasting behavior of the horse heart and yeast proteins. Sinibaldi, F., et al. J. Inorg. Biochem. 105, 1365-1372, (2011)

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Peroxynitrite detoxification by horse heart carboxymethylated cytochrome c is allosterically modulated by cardiolipin. Ascenzi, P., et al. Biochem. Biophys. Res. Commun. 415, 463-467, (2011)

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Novel biomarkers of protein oxidation sites and degrees using horse cytochrome c as the target by mass spectrometry Zong, W., et al. Spectrochim. Acta A 78, 1581-1586, (2011)

Merck 14,2791