Synonym: 3β-Hydroxy-5-cholestene 3-arachidonate, 5-Cholesten-3β-ol 3-arachidonate, Cholesteryl eicosatetraenoate
|Related Categories||Biochemicals and Reagents, Cell Biology, Cholesterol and Derivatives, Lipids, Metabolic Pathways,|
|assay||≥95% (HPLC; detection at 205 nm)|
|shipped in||dry ice|
Cholesteryl arachidonate is a clear, colorless viscous liquid in chloroform.
Cholesteryl arachidoante was oxidized and used to study the biological effects.1,2
Cholesteryl arachidonate is a cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters.3 The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.4
To more efficiently transport both dietary and synthesized cholesterol, it is converted to cholesteryl esters. Free cholesterol can be taken up by lipoproteins, but is confined to the outer surface o...
BioFiles 2007, 2.7, 10.
3. Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle Krieger M et al J. Biol. Chem. 253, 4093-101, (1978)
Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid. Do TQ, Moshkani S, et al. J. Immunol. 181, 4177-4187, (2008)
Acetylated low density lipoprotein inhibits the incorporation of arachidonic acid in phospholipids with a concomitant increase of cholesterol arachidonate in rat peritoneal macrophages. Pollaud C, Krause S, Lepert JC, et al. Biochim. Biophys. Acta 1259(3), 211-9, (1995)
The mobility of cholesteryl esters in native and reconstituted low density lipoprotein as monitored by nuclear magnetic resonance spectroscopy. Kroon PA and Krieger M J. Biol. Chem. 256(11), 5340-4, (1981)
Novel surface phase containing cholesteryl esters. 2. Nonequivalence of cholesteryl arachidonate and those with 18-carbon, cis-unsaturated acyl groups. Smaby JM and Brockman HL Biochemistry 20(4), 724-30, (1981)
Ceroid accumulation by murine peritoneal macrophages exposed to artificial lipoproteins: ultrastructural observations. Ball RY, Carpenter KL, and Mitchinson MJ Br. J. Exp. Pathol. 69(1), 43-56, (1988)
Microquantification of cholesterol and cholesteryl esters in rat peritoneal macrophages by reverse-phase high-performance liquid chromatography. Araki N, Horiuchi S, Rahim AT, et al. Anal. Biochem. 185(2), 339-45, (1990)
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