Synonym: 3β-Hydroxy-5-cholestene 3-oleate, 5-Cholesten-3β-ol 3-oleate, Cholesteryl cis-9-octadecenoate, Oleic acid cholesteryl ester
|Related Categories||Biochemicals and Reagents, Cell Biology, Cholesteric, Cholesterol and Derivatives, Lipids,|
|assay||≥98% (HPLC; detection at 205 nm)|
1 g in serum bottle
100, 250, 500 mg in serum bottle
Cholesteryl oleate yields a clear, colorless solution in chloroform at 100 mg/ml.
Cholesteryl oleate was used to study the ability of silicone hydrogel contact lenses to absorb tear lipids,1 cholesterol and cholesterol esters.2 It was also used in the development of amperometric cholesterol biosensors.3
Cholesterol in plasma is present in an esterified form such as Cholesteryl oleate.4 The liver is a primary source of cholesteryl oleate that enriches the LDL particles when released into plasma. The secretion of lipoproteins enriched with cholesteryl oleate has close correlation with the pathogenesis of coronary artery atherosclerosis.5
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To more efficiently transport both dietary and synthesized cholesterol, it is converted to cholesteryl esters. Free cholesterol can be taken up by lipoproteins, but is confined to the outer surface o...
BioFiles 2007, 2.7, 10.
3. Design of an Interference-Free Cholesterol Amperometric Biosensor Based on the Electrosynthesis of Polymeric Films of Diaminonaphthalene Isomers García-Ruiz E et al Electroanalysis 16, 497-504, (2004)
Use of cholesterol-rich nanoparticles that bind to lipoprotein receptors as a vehicle to paclitaxel in the treatment of breast cancer: pharmacokinetics, tumor uptake and a pilot clinical study. Pires LA, Hegg R, Valduga CJ, et al. Cancer Chemother. Pharmacol. 63, 281-287, (2009)
Uptake by breast carcinoma of a lipidic nanoemulsion after intralesional injection into the patients: a new strategy for neoadjuvant chemotherapy. Mendes S, Graziani SR, et al. Gynecol. Oncol. 112, 400-404, (2009)
Upregulating reverse cholesterol transport with cholesteryl ester transfer protein inhibition requires combination with the LDL-lowering drug berberine in dyslipidemic hamsters. Briand F, Thieblemont Q, Muzotte E, et al. Arterioscler. Thromb. Vasc. Biol. 33(1), 13-23, (2013)
Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Ohshiro T, Matsuda D, Sakai K, et al. Arterioscler. Thromb. Vasc. Biol. 31(5), 1108-15, (2011)
Modification of composition of a nanoemulsion with different cholesteryl ester molecular species: effects on stability, peroxidation, and cell uptake. Almeida CP, Vital CG, Contente TC, et al. Int. J. Nanomedicine 5, 679-86, (2010)
Calculation of the T-X phase diagrams for binary mixtures of cholestanyl myristate-cholesteryl myristate and cholestanyl myristate-cholesteryl oleate. Yurtseven H and Sen S Ann. N. Y. Acad. Sci. 1161, 416-28, (2009)
Metabolism of triglyceride-rich lipoproteins and transfer of lipids to high-density lipoproteins (HDL) in vegan and omnivore subjects. Vinagre JC, Vinagre CG, Pozzi FS, et al. Nutr. Metab. Cardiovasc. Dis. 23(1), 61-7, (2013)
Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion. Paillasse MR, de Medina P, Amouroux G, et al. J. Lipid Res. 50(11), 2203-11, (2009)
Atomistic simulations of phosphatidylcholines and cholesteryl esters in high-density lipoprotein-sized lipid droplet and trilayer: clues to cholesteryl ester transport and storage. Koivuniemi A, Heikelä M, Kovanen PT, et al. Biophys. J. 96(10), 4099-108, (2009)
Lipolysis of emulsion models of triglyceride-rich lipoproteins is altered in male patients with abdominal aorta aneurysm. Hosni JJ, Vinagre CG, Mady C, et al. Braz. J. Med. Biol. Res. 40(3), 305-7, (2007)
Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. Adam O, Wolfram G, and Zöllner N Ann. Nutr. Metab. 47(1), 31-6, (2003)
Lecithin cholesterol acyltransferase in human cerebrospinal fluid: reduced level in patients with multiple sclerosis and evidence of direct synthesis in the brain. Albers JJ, Marcovina SM, and Christenson RH Int. J. Clin. Lab. Res. 22(3), 169-72, (1992)
Induced circular dichroism of incorporated fluorescent cholesteryl esters and polar lipids as a probe of human serum low density lipoprotein structure and melting. Sklar LA, Craig IF, and Pownall HJ J. Biol. Chem. 256(9), 4286-92, (1981)
Cholesteryl esters in lymph chylomicrons: contribution from high density lipoprotein transferred from plasma into intestinal lymph. Oliveira HC, Nilausen K, Meinertz H, et al. J. Lipid Res. 34(10), 1729-36, (1993)
Processing of cholesteryl ester from low-density lipoproteins in the rat. Hepatic metabolism and biliary secretion after uptake by different hepatic cell types. Kuipers F, Nagelkerke JF, Bakkeren H, et al. Biochem. J. 257(3), 699-704, (1989)
FT-IR 1 (1), 1060:B / RegBook 1 (2), 2871:F / Structure Index 1, 460:D:2
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