Doxercalciferol
≥98% (HPLC), solubility: >10 mg/mL in DMSO
DOWNLOAD MSDS (PDF)Synonym:
(5Z,7E,22E)
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CAS Number 54573-75-0
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Empirical Formula (Hill Notation) C28H44O2
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Molecular Weight 412.65
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MDL number MFCD00871065
Properties
| Related Categories | Cell Biology, Cell Signaling and Neuroscience, Gene Regulation, Gene Regulation and Expression, Metabolic Pathways, |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| solubility | DMSO: >10 mg/mL |
| shipped in | wet ice |
| storage temp. | −20°C |
Description
Biochem/physiol Actions
Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4.
Doxercalciferol is a vitamin D2 analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D2. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR.
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