14-3-3 Epsilon histidine-tagged human
recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous solution
DOWNLOAD MSDS (PDF)Synonym:
14-3-3ε,
FLJ45465,
KCIP-1,
MDCR,
MDS,
Tyrosine 3-
-
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Properties
| Related Categories | Apoptosis and Cell Cycle, Cell Biology, Cell Cycle Proteins and Antibodies, Cell Cycle Regulators, Cell Signaling and Neuroscience More... |
| recombinant | expressed in E. coli |
| assay | ≥90% (SDS-PAGE) |
| form | buffered aqueous solution |
| shipped in | dry ice |
| storage temp. | −20°C |
| Gene Information | human ... YWHAE(7531) |
Description
Physical form
Supplied as a 0.2 μm filtered solution in 50 mM potassium phosphate buffer and 300 mM sodium chloride.
Biochem/physiol Actions
14-3-3 proteins are involved in a multitude of biological processes and exhibit a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control.1,2 14-3-3ε interacts with various proteins (cdc25 phosphatases, Raf1, and IRS1) in diverse signal trasduction pathways suggesting a role to 14-3-3ε in biological phenomenons such as cell division and regulation of insulin sensitivity.3,4 There is a growing emergence of correlative data linking 14-3-3 proteins to various human diseases such as neurodegenerative conditions, cancer, and heart diseases.1
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