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E2656 Sigma

(−)-Epothilone B

from Sorangium cellulosum, ≥98% (HPLC)

Synonym: EPO906, EpoB, Patupilone

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents,
biological source   from Sorangium cellulosum
InChI Key   QXRSDHAAWVKZLJ-PVYNADRNSA-N
assay   ≥98% (HPLC)
form   lyophilized powder
storage condition   desiccated
  protect from light
color   white to off-white
storage temp.   −20°C

Description

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

(-)-Epothilone B is a microtubule (MT) stabilizing drug and natural macrolide antitumor from myxobacteria Sorangium cellulosum. EpoB has similar biological properties to EpoA. However, EpoB is 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells). (-)-Epothilone B is similar to paclitaxel in binding displacement, and a substitution for paclitaxel in dependent cell growth. EpoB causes cell cycle arrest (IC50 = 3.5 nM).

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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E3656 (−)-Epothilone A, from Sorangium cellulosum, >95% (HPLC), solid

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