Ganciclovir ≥99% (HPLC), powder

Properties

Related Categories	AIDS and Viral Research Reagents, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antitumor Agents, Antiviral, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, DNA Synthesis Inhibitors, G, Immune Cell Signaling and Blood, Immune System Regulation, Interferes with DNA Synthesis, Mechanism of Action, Nucleosides, Roche, Spectrum of Activity More...
Quality Level	PREMIUM
assay	≥99% (HPLC)
form	powder
color	white
solubility	0.1 M HCl: soluble10 mg/mL
abs.	ε1mM/256 nm 12.0
storage temp.	2-8°C

Description

Application

Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required.

Biochem/physiol Actions

Ganciclovir is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research.
Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell.¹ The cell cycle is irreversibly arrested at the G2-M checkpoint.² Gap junction involvement in the ganciclovir bystander effect has been studied.³ Ganciclovir has been used to study loss of telomeres⁴ and to evaluate sensitivity of viruses to antiviral treatments.⁵

Price and Availability

Related Papers

1. Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells. Rubsam, L.Z., et al. Cancer Res. 59, 675, (1999)

Documents

Certificate of Analysis

Certificate of Origin

G2536 - Product Information Sheet (85KB)

Safety Information

Symbol	GHS08
Signal word	Danger
Hazard statements	H360
Precautionary statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes (Europe)	T
Risk Statements (Europe)	46-60-61
Safety Statements (Europe)	53-36/37/39-45
WGK Germany	3
RTECS	MF8407000

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

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