Geldanamycin from Streptomyces hygroscopicus
≥98% (HPLC), powder
DOWNLOAD MSDS (PDF)-
CAS Number 30562-34-6
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Empirical Formula (Hill Notation) C29H40N2O9
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Molecular Weight 560.64
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MDL number MFCD00274570
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Popular Documents: Datasheet (PDF)
Properties
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, |
| Quality Level | PREMIUM |
| assay | ≥98% (HPLC) |
| form | powder |
| color | yellow to orange |
| solubility | DMSO: soluble |
| storage temp. | −20°C |
Description
Biochem/physiol Actions
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
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>98% (HPLC), powder
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