Guanosine 5′-triphosphate lithium salt
~95% (HPLC), powder
DOWNLOAD MSDS (PDF)Synonym: GTP lithium salt
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CAS Number 85737-04-8
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Empirical Formula (Hill Notation) C10H16N5O14P3 · xLi+
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Molecular Weight 523.18 (free acid basis)
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MDL number MFCD00070012
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PubChem Substance ID 24895236
Properties
| Related Categories | Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cofactors, |
| assay | ~95% (HPLC) |
| form | powder |
| color | white |
| solubility | H2O: soluble100 mg/mL |
| shipped in | dry ice |
| storage temp. | −20°C |
Description
Caution
Stability is much better than sodium salt.
Preparation Note
Prepared by enzymatic phosphorylation of 5′-GMP.
Biochem/physiol Actions
GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
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