|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Gastrointestinal Peptides, Neuropeptide Y, Neuropeptide Y and Peptide YY,|
|Gene Information||human ... GAL(51083), NPY(4852)|
This chimeric peptide is a high affinity galanin receptor antagonist (IC50=0.1 nM in rat hypothalamus membranes and Kd=0.01 nm in rat spinal cord membranes). This peptide is also recognized by neuropeptide Y receptors (IC50=0.25 μM in rat cerebral cortex membranes) and is a Y2 agonist in rat vas deferens.
Galanin is a 30 amino acid non-amidated peptide in humans and identified in 14 other species as a 29 amino acid C-terminally amidated peptide. Galanin is widely distributed in both the central and pe...
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