Hydrocortisone

Papers

Loss Of STAT1 From Mouse Mammary Epithelium Results In An Increased Neu-induced Tumor Burden. Klover, P.J., et al. Neoplasia 12, 899-905, (2010)

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A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells. Castiel, A., et al. BMC Cancer 11, 412, (2011)

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Analysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy. Jodhbir S. Mehta et al Mol. Vis. 14, 1277-81, (2008)

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Determination of the fate and contribution of ex vivo expanded human bone marrow stem and progenitor cells for bone formation by 2.3ColGFP. Dezhong Yin et al Mol. Ther. 17, 1967-78, (2009)

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LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis. Huili Li et al Mol. Cancer 10, 100, (2011)

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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)

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Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Yong-Hua Wang et al Bioorg. Med. Chem. Lett. 15, 4076-84, (2005)

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The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening. Daniela Schuster et al J. Med. Chem. 49, 3454-66, (2006)

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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Giorgio Ottaviani et al J. Med. Chem. 49, 3948-54, (2006)

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Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. Trond Ulven et al J. Med. Chem. 49, 6638-41, (2006)

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Microwave-enhanced nucleophilic fluorination in the synthesis of fluoropyridyl derivatives of [3,2-c]pyrazolo-corticosteroids, potential glucocorticoid receptor-mediated imaging agents. Michael G C Kahn et al Bioorg. Med. Chem. Lett. 16, 3454-8, (2006)

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Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers. Motohiko Ukiya et al J. Nat. Prod. 69, 1692-6, (2006)

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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

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Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety. Lei Fang et al Bioorg. Med. Chem. Lett. 17, 1062-6, (2007)

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QSAR study on permeability of hydrophobic compounds with artificial membranes. Masaaki Fujikawa et al Bioorg. Med. Chem. 15, 3756-67, (2007)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential. Kamel A Metwally et al Eur. J. Med. Chem. 42, 152-60, (2007)

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Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. Christopher A Elkins et al Antimicrob. Agents Chemother. 51, 923-9, (2007)

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Triterpene glycosides from the flower petals of sunflower (Helianthus annuus) and their anti-inflammatory activity. Motohiko Ukiya et al J. Nat. Prod. 70, 813-6, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin. Artem Cherkasov et al J. Med. Chem. 51, 2047-56, (2008)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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Determination of log D via automated microfluidic liquid-liquid extraction. Muhammad Alimuddin et al J. Med. Chem. 51, 5140-2, (2008)

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Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes. Hisashi Matsuda et al Bioorg. Med. Chem. Lett. 18, 2038-42, (2008)

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Steroids and flavonoids from Physalis alkekengi var. franchetii and their inhibitory effects on nitric oxide production. Li Qiu et al J. Nat. Prod. 71, 642-6, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Hong Wan et al J. Med. Chem. 52, 1693-700, (2009)

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Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. José Marco-Contelles et al J. Med. Chem. 52, 2724-32, (2009)

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Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. Pelayo Camps et al J. Med. Chem. 52, 5365-79, (2009)

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Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Mariana P Arce et al J. Med. Chem. 52, 7249-57, (2009)

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Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Edith Bellavance et al J. Med. Chem. 52, 7488-502, (2009)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Hepatoprotective amide constituents from the fruit of Piper chaba: Structural requirements, mode of action, and new amides. Hisashi Matsuda et al Bioorg. Med. Chem. 17, 7313-23, (2009)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds. Marjan Van Cleemput et al J. Nat. Prod. 72, 1220-30, (2009)

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

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Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Pil H Lee et al Bioorg. Med. Chem. Lett. 20, 69-73, (2010)

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Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. Toshio Morikawa et al Bioorg. Med. Chem. 18, 1882-90, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Quassidines A-D, bis-beta-carboline alkaloids from the stems of Picrasma quassioides. Wei-Hua Jiao et al J. Nat. Prod. 73, 167-71, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. Tadashi Honda et al J. Med. Chem. 54, 1762-78, (2011)

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Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages. Jun Li et al Bioorg. Med. Chem. Lett. 21, 5363-9, (2011)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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Prediction of drug intestinal absorption by new linear and non-linear QSPR. Alan Talevi et al Eur. J. Med. Chem. 46, 218-28, (2011)

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N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. Gema C González-Muñoz et al Eur. J. Med. Chem. 46, 2224-35, (2011)

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Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced ?-amyloid aggregation inhibitors. Huang Tang et al Eur. J. Med. Chem. 46, 4970-9, (2011)

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Anti-inflammatory triterpenes from the leaves of Rosa laevigata. Na Zeng et al J. Nat. Prod. 74, 732-8, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Huang Tang et al Bioorg. Med. Chem. Lett. 22, 2257-61, (2012)

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Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. Miriam Redondo et al Eur. J. Med. Chem. 47, 175-85, (2012)

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A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation. Gianpaolo Chiriano et al Eur. J. Med. Chem. 48, 206-13, (2012)

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Merck 14,4787

Beil. 8,IV,3422

Corp MSDS 1 (1), 1894:B / FT-IR 2 (3), 4233:A / FT-NMR 1 (3), 584:C / RegBook 1 (2), 2863:G / Sigma FT-IR 1 (1), 1259:B / Structure Index 1, 458:D:6