|Related Categories||Anticoagulants, Biochemicals and Reagents, Blood, Cell Biology, Cell Signaling and Neuroscience,|
Hirudin fragment that binds to the regulatory exosite I on thrombin and the regulatory proexosite I on prothrombin. The interaction with thrombin prevents the thrombin-induced activation of clotting factor V. The interaction with prothrombin inhibits the formation of thrombin by factor Xa in the presence of factor Va.
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lyophilized powder, ≥1,500 ATU/mg protein (ATU = antithrombin units)
recombinant, expressed in Saccharomyces cerevisiae, ≥7,000 ATU/mg protein (ATU = antithrombin units)
lyophilized powder, 300-1,500 ATU/mg protein (ATU = antithrombin units)
lyophilized powder, white, >1500 U/vial
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BioFiles v7 n5, 2012, 25–26
Keywords: Anticoagulants, Cardiovascular, Pharmaceutical
Demonstration of exosite I-dependent interactions of thrombin with human factor V and factor Va involving the factor Va heavy chain: analysis by affinity chromatography employing a novel method for active-site-selective immobilization of serine proteinases. Dharmawardana, K.R., and Bock, P.E. Biochemistry 37, 13143-13152, (1998)
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