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I0523 Sigma

Interleukin-2 from mouse

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

DOWNLOAD MSDS (PDF)

Synonym: IL-2, T-cell growth factor, mIL-2

Description

Analysis Note

Activity was determined by dose-dependent stimulation of murine CTLL-2 cells. ED50 : ≤ 0.2 ng/ml (corresponds to a specific activity of 5 × 106 units/mg)

Biochem/physiol Actions

Interleukin-2 is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of activated T cells and related cell types. Interleukin-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in 10 mM sodium citrate, pH 4.0.

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