|Related Categories||Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines,|
|biological source||from human (osteosarcoma cells)|
|suitability||suitable for cell culture|
|shipped in||dry ice|
Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.
Produced in MG-63 osteosarcoma cells induced with human IL-1β.1
One unit equals the amount of IL-6 required to induce half maximal proliferation of T-1165 cell in vitro.
Solution in 0.2 μm filtered phosphate buffered saline containing 0.1% human serum albumin.
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Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, carrier free
IL-6, recombinant, expressed in E. coli, Animal Component Free
IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
IL-6, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
A broad array of molecules can be functionally termed cytokines. These secreted or membrane-bound regulatory factors control myriad developmental, metabolic and host defense processes in cells that d...
The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages...
BioFiles 2009, 4.5, 16.
Keywords: Anti-inflammatory agents, Antitumor agents, Cancer, Cell proliferation, Gene expression, Growth factors, Transcription
Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Gauldie, J., et al. Proc. Natl. Acad. Sci. U. S. A. 84, 7251, (1987)
Hirano, T. The Cytokine Handbook 3rd ed.,, (1998), 197
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