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K2010 - α-Ketoglutaric acid sodium salt

K2010 Sigma

α-Ketoglutaric acid sodium salt

BioUltra

Synonym: 2-Oxoglutaric acid monosodium salt, 2-Oxopentanedioic acid monosodium salt, Sodium 2-oxoglutarate monobasic

CAS Number 22202-68-2
Linear Formula HOOCCH₂CH₂COCOONa
Molecular Weight 168.08
Beilstein Registry Number 4597521
EC Number 244-836-6
MDL number MFCD00064196
PubChem Substance ID 24896216
Popular Documents: Specification Sheet (PDF) | RAMAN FTIR (PDF)

α-Ketoglutaric acid sodium salt BioUltra

Properties

Related Categories	Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Glutamic Dehydrogenase, L-, Isocitrate Dehydrogenase (IDH) Substrates and Reaction Products, Isocitrate Dehydrogenase (IDH) in Cancer Metabolism, Ketoglutarate Dehydrogenase, alpha, Substrates by Enzyme More...
product line	BioUltra
impurities	≤0.0005% Phosphorus (P)
	≤0.1% Insoluble matter
solubility	H₂O: soluble0.5 M, clear, colorless
anion traces	chloride (Cl^-): ≤0.05%
	sulfate (SO₄^2-): ≤0.05%
cation traces	Al: ≤0.0005%
	Ca: ≤0.001%
	Cu: ≤0.0005%
	Fe: ≤0.0005%
	K: ≤0.005%
	Mg: ≤0.0005%
	NH₄⁺: ≤0.05%
	Pb: ≤0.001%
	Zn: ≤0.0005%
storage temp.	2-8°C

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Description

Biochem/physiol Actions

α-Ketoglutaric acid is a key intermediate in the TCA Cycle. It also plays an important role in preventing nitrogen overload by combining with nitrogen released within the cell.

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Articles

Citric Acid Cycle

Acetyl-CoA enters a cycle whose discovery by Hans Krebs 70 years ago marked a milestone in biochemistry. The citric acid cycle is also termed the tricarboxylic acid cycle, TCA cycle or Krebs cycle (s...
BioFiles 2007, 2.6, 16.
Keywords: Addition reactions, Biochemistry, Catalysis, Citric Acid Cycle, Decarboxylations, Dehydration reaction, Hydration reaction, Metabolites, Oxidations, Phosphorylations

Fatty Acid Synthesis and Metabolism in Cancer Cells

Proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sour...
Keywords: Apoptosis, Cancer, Carboxylations, Catalysis, Gene expression, Glycolysis, Metabolism, Oxidations, PAGE, Phosphorylations

Glutamine Metabolism is Dysregulated in Many Cancer Cells

Proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metab...
Keywords: Aerobic, Cancer, Gene expression, Glycolysis, Metabolism, Metabolites, PAGE, Phosphorylations, Transcription

LCMS Separation and Identification of 2-Hydroxyglutarates

Sigma-Aldrich has recently developed an application for the separation and identification of S-2-hydroxyglutaric acids and R-2-hydroxyglutaric acids by chiral LC-MS, using a CHIROBIOTIC® R Column (co...
Keywords: AGE, Cancer, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Reductions, Separation

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