|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, Liver Preparations and Fractions, Multi-Drug Resistance and Drug Metabolism,|
|biological source||from human male|
|assay||~10 mg per vial|
|shipped in||dry ice|
Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. 1 They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes. 2
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.
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The Carbon Monoxide-binding pigment of liver microsomes II. Solubilization, purification and properties. Omura, T. and Sato, R. J. Biochem. 239, 2379-85, (1964)
Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles by liver microsomes: interspecies differences and structure-metabolism relationships. VASHISHTHA, S. Drug Metab. Dispos. 30, 1070-1076, (2002)
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