Microsomes from Liver, Pooled
from human male
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Properties
| Related Categories | Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, Liver Preparations and Fractions, Multi-Drug Resistance and Drug Metabolism, |
| biological source | from human male |
| assay | ~10 mg per vial |
| shipped in | dry ice |
| storage temp. | −70°C |
Description
Application
Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. 1 They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes. 2
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.
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