Mycophenolic acid

Papers

Conditional Knockout Of Nucleolin In DT40 Cells Reveals The Functional Redundancy Of Its RNA-binding Domains. Storck, S., et al. Biol. Cell 101, 153-67, (2009)

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Appraising The Roles Of CBLL1 And The Ubiquitin/Proteasome System For Flavivirus Entry And Replication. Fernandez-Garcia, M.D., et al. J. Virol. 85, 2980-9, (2011)

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UDP-glucuronosyltransferases and clinical drug-drug interactions. Tony K L Kiang et al Pharmacol. Ther. 106, 97-132, (2005)

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Identification of compounds with anti-West Nile Virus activity. John R Goodell et al J. Med. Chem. 49, 2127-37, (2006)

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Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. Curtis R Chong et al J. Med. Chem. 49, 2677-80, (2006)

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Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH. Watkins, W. J.; et al. Bioorg. Med. Chem. Lett. 16, 3479, (2006)

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Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). Scott H Watterson et al J. Med. Chem. 50, 3730-42, (2007)

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Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues. Liqiang Chen et al J. Med. Chem. 50, 5743-51, (2007)

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Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. Liqiang Chen et al J. Med. Chem. 50, 6685-91, (2007)

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Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model. Niclas W Schiffer et al J. Biol. Chem. 282, 9195-203, (2007)

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Mycophenolic acid as a latent agonist of PPARgamma. Makoto Ubukata et al Bioorg. Med. Chem. Lett. 17, 4767-70, (2007)

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Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

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Activity of ribavirin against Hantaan virus correlates with production of ribavirin-5'-triphosphate, not with inhibition of IMP dehydrogenase. Yanjie Sun et al Antimicrob. Agents Chemother. 51, 84-8, (2007)

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c-Src protein kinase inhibitors block assembly and maturation of dengue virus. J J H Chu et al Proc. Natl. Acad. Sci. U. S. A. 104, 3520-5, (2007)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors. Chung-Kyu Ryu et al Bioorg. Med. Chem. Lett. 18, 2948-51, (2008)

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Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Liqiang Chen et al Bioorg. Med. Chem. 16, 7462-9, (2008)

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Mycophenolic acid analogs with a modified metabolic profile. Liqiang Chen et al Bioorg. Med. Chem. 16, 9340-5, (2008)

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Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus. Markus Mezger et al Antimicrob. Agents Chemother. 52, 2644-6, (2008)

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Mycophenolic derivatives from Eupenicillium parvum. Eman Habib et al J. Nat. Prod. 71, 1915-8, (2008)

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The medicinal chemistry of dengue fever. Andrew J Stevens et al J. Med. Chem. 52, 7911-26, (2009)

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Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives. Michele Tonelli et al Bioorg. Med. Chem. 17, 4425-40, (2009)

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Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks. Francisco J Prado-Prado et al Bioorg. Med. Chem. 17, 569-75, (2009)

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Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis. Liqiang Chen et al J. Med. Chem. 53, 4768-78, (2010)

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Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives. Michele Tonelli et al Bioorg. Med. Chem. 18, 2937-53, (2010)

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Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives. Shinya Mitsuhashi et al Bioorg. Med. Chem. 18, 8106-11, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Nidhi Puri et al Eur. J. Med. Chem. 45, 4813-26, (2010)

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Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain. Krzysztof Felczak et al Bioorg. Med. Chem. 19, 1594-605, (2011)

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Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors A. Carta, et al., Bioorg. Med. Chem. 19, 7070-7084, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivatives. Na Yang et al Bioorg. Med. Chem. Lett. 22, 53-6, (2012)

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Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics. Gummert, J.F., et al. J. Pharmacol. Exp. Ther. 291, 1100-1112, (1999)

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Conformational changes and stabilization of inosine 5'-monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid. Nimmesgern, E., et al. J. Biol. Chem. 271, 19421-19427, (1996)

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Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Senda, M., et al. Transplantation 60, 1143-1148, (1995)

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Merck 14,6327