|Related Categories||Antibiotic powders, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application,|
|solubility||methanol: soluble50 mg/mL|
|suitability||suitable for cell culture|
|Gene Information||human ... IMPDH1(3614), IMPDH2(3615)|
Recommended for use as a selection agent at 25 μg/ml.
Used to select animal cells expressing the Escherichia coli gene for xanthine-guanine phosphosribosyl transferase.
Immunosuppressive agent. Suppresses cytokine-induced nitric oxide production.
Immunosuppressive agent. Used to inhibit early stage biosynthesis of purine nucleotides. Used as a specific inhibitor of inosine 5′-monophosphate (IMP) dehydrogenase (IMPDH) and inducer of IMP dehydrogenase gene expression.
Certificate of Analysis
Certificate of Origin
|Symbol||GHS07, GHS08, GHS09|
|Precautionary statements||P201-P273-P281-P308 + P313-P501|
|Target organs||Immune system|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T,N|
|Risk Statements (Europe)||61-22-48/25-50/53-68|
|Safety Statements (Europe)||53-22-45-61|
Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). Scott H Watterson et al J. Med. Chem. 50, 3730-42, (2007)
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues. Liqiang Chen et al J. Med. Chem. 50, 5743-51, (2007)
Activity of ribavirin against Hantaan virus correlates with production of ribavirin-5'-triphosphate, not with inhibition of IMP dehydrogenase. Yanjie Sun et al Antimicrob. Agents Chemother. 51, 84-8, (2007)
Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus. Markus Mezger et al Antimicrob. Agents Chemother. 52, 2644-6, (2008)
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks. Francisco J Prado-Prado et al Bioorg. Med. Chem. 17, 569-75, (2009)
Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives. Shinya Mitsuhashi et al Bioorg. Med. Chem. 18, 8106-11, (2010)
Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors A. Carta, et al., Bioorg. Med. Chem. 19, 7070-7084, (2011)
Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics. Gummert, J.F., et al. J. Pharmacol. Exp. Ther. 291, 1100-1112, (1999)
Conformational changes and stabilization of inosine 5'-monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid. Nimmesgern, E., et al. J. Biol. Chem. 271, 19421-19427, (1996)
Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Senda, M., et al. Transplantation 60, 1143-1148, (1995)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?