Synonym: 9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride
|Related Categories||Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors, Cell Biology,|
|solubility||H2O: soluble50 mg/mL|
Selective norepinephrine uptake inhibitor.
Certificate of Analysis
Certificate of Origin
Following vesicular release, the biogenic amine neurotransmitters, norepinephrine (A7257), dopamine (H8502) and serotonin (H9523), are removed from the extracellular space by selective and pharmacolo...
Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine. Rotzinger, et al. Cell. Mol. Neurobiol. 19, 427-442, (1999)
Autoradiographic studies on the uptake of 3H-noradrenaline and 3H-serotonin by neurones and astrocytes in explant and primary cultures of rat CNS: effects of antidepressants. Hosli, E., and Hosli, L. Int. J. Dev. Neurosci. 13, 897-908, (1995)
[The delayed sensitization of CRH response developed after chronic variable stress on the acoustic startle reflex]. Fujiwara K, Asakura M, Yanagida T, et al. Nihon Shinkei Seishin Yakurigaku Zasshi 31(1), 17-22, (2011)
Effects of repeated maprotiline and fluoxetine treatment on gene expression of catecholamine synthesizing enzymes in adrenal medulla of unstressed and stressed rats. Spasojevic N, Gavrilovic L, and Dronjak S Auton. Autacoid Pharmacol. 30(4), 213-7, (2010)
Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data. Lauterbach EC, Victoroff J, Coburn KL, et al. J. Neuropsychiatry Clin. Neurosci. 22(1), 8-18, (2010)
The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters. Cloonan SM, Drozgowska A, Fayne D, et al. Leuk. Lymphoma 51(3), 523-39, (2010)
Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids? Lee LH, Shui G, Farooqui AA, et al. Int. J. Neuropsychopharmacol. 12(7), 953-64, (2009)
[Antidepressants with different action mechanisms in the treatment of chronic daily headache]. Amelin AV, Tarasova SV, Ignatov IuD, et al. Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 107(9), 38-44, (2007)
Effects of noradrenaline and serotonin reuptake inhibitors on pituitary-adrenocortical and sympatho-adrenomedullar system of adult rats. Dronjak S, Spasojevic N, Gavrilovic L, et al. Neuro Endocrinol. Lett. 28(5), 614-20, (2007)
Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity. Pinar M, Gulsun M, Tasci I, et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 32(1), 135-9, (2008)
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